2021 Global Biofoundries Alliance Webinar Series
April 20, 2021
Dr Rosalind Le Feuvre
Director of Operations, SYNBIOCHEM and Future BRH,
Manchester Institute of Biotechnology, UK
Rapid prototyping and automated strain engineering for
next-generation sustainable biomanufacturing.
The application of predictive synthetic biology to rapidly
engineer microbial cell factories promises to deliver new
sustainable chemicals biomanufacture across industrial sectors
(e.g., pharmaceuticals, green chemistry, novel materials, and
advanced synthetic fuels).
In this Manchester Biofoundry talk I will discuss the
development of an automated compound agnostic
Design/Build/Test/Learn pipeline that integrates design software
tools, automated build workflows and optimised analytical test
screening to rapidly prototype microbial production routes for diverse chemicals/materials
The transition from laboratory prototyping to production at scale and delivery of next-generation
sustainable biomanufacturing processes requires major technical, scientific and economic
challenges to be overcome.
Global Biofoundries will play a central role in the development of agile pipelines and reduce the
delivery time from initial strain screening and prototyping towards industrial production that will
accelerate the delivery of economically attractive, robust and scalable biomanufacturing
processes to meet societal and commercial demand.
Dr. Mark Dörr
Head of LARA Platform, Institute for Biochemistry,
University Greifswald, Germany
Robot and machine learning assisted protein engineering
on the high-throughput screening platform LARA.
The University Greifswald robotic platform LARA (lara.uni-
greifswald.de) is designed for high-throughput protein/enzyme
screening. It consists of a central industrial robotic arm (Fanuc)
serving 4 incubators (Thermo Cytomat 2), one centrifuge
(Hettich Rotanta 460 R), one liquid handling station (Agilent
bravo) and two plate readers (Thermo varioskan).